Defending champion Djokovic and five-time winner Williams are both current world number ones and their top billing was a formality.
Former number one Nadal, the Wimbledon champion in 2008 and 2010, has endured a miserable record at the All England Club in recent times, losing in the second, first and fourth round on his last three visits.
He was dethroned as French Open champion this season and despite winning the grass-court title in Stuttgart, he was then bundled out of Queen’s by Ukrainian journeyman Alexander Dolgopolov in his opening match.
As 10th seed, Nadal could play one of his major rivals such as Djokovic, seven-time champion Roger Federer or 2013 winner Andy Murray as early as the fourth round at Wimbledon which gets under way on Monday.
Federer, fresh from his eighth Halle grass-court title, is seeded two with Murray at three.
Behind Williams, who is bidding to clinch her third major of the year after winning the Australian and French Opens, defending Wimbledon champion Petra Kvitova is seeded second.
Romania’s Simona Halep takes the third seeding ahead of Maria Sharapova, the 2004 champion.
With the exception of Canada’s Milos Raonic, a semi-finalist in 2014, being seeded one spot above Spanish veteran David Ferrer, the seedings remained true to the current top 10 rankings in both the men’s and women’s tournaments.
Top 16 men’s seeds:
1. Novak Djokovic (SRB), 2. Roger Federer (SUI), 3. Andy Murray (GBR), 4. Stan Wawrinka (SUI), 5. Kei Nishikori (JPN), 6. Tomas Berdych (CZE), 7. Milos Raonic (CAN), 8. David Ferrer (ESP), 9. Marin Cilic (CRO), 10 Rafael Nadal (ESP), 11 Grigor Dimitrov (BUL), 12 Gilles Simon (FRA), 13 Jo-Wilfried Tsonga (FRA), 14 Kevin Anderson (RSA), 15 Feliciano Lopez (ESP), 16 David Goffin (BEL)
Top 16 women’s seeds:
1 Serena Williams (USA), 2 Petra Kvitova (CZE), 3 Simona Halep (ROM), 4 Maria Sharapova (RUS), 5 Caroline Wozniacki (DEN), 6 Lucie Safarova (CZE), 7 Ana Ivanovic (SRB), 8 Ekaterina Makarova (RUS), 9 Carla Suarez Navarro (ESP), 10 Angelique Kerber (GER), 11 Karolina Pliskova (CZE), 12 Eugenie Bouchard (CAN), 13 Agnieszka Radwanska (POL), 14 Andrea Petkovic (GER), 15 Timea Bacsinszky (SUI), 16 Venus Williams (USA) — AFP